{"id":20867,"date":"2026-10-13T09:31:30","date_gmt":"2026-10-13T02:31:30","guid":{"rendered":"https:\/\/www.vietstock.org\/?p=20867"},"modified":"2026-10-13T13:35:19","modified_gmt":"2026-10-13T06:35:19","slug":"tylosin-veterinary-medicine-uses-resistance-withdrawal","status":"publish","type":"post","link":"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/","title":{"rendered":"Tylosin in Veterinary Medicine: Scope of Use, Antimicrobial Resistance, and Residue Considerations"},"content":{"rendered":"<p><b>Tylosin in veterinary medicine<\/b><span style=\"font-weight: 400;\"> is a macrolide antibiotic used to treat certain bacterial infections in animals caused by susceptible organisms. This active ingredient is particularly relevant in the management of some respiratory diseases in pigs and poultry associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, signs such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coughing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced feed intake.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Respiratory discharge.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An increasing disease incidence within the herd or flock.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">do not mean that tylosin is always an appropriate choice.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Respiratory disease may involve viruses, bacteria, <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">, housing conditions, or several factors occurring at the same time. Even when tylosin helps reduce clinical signs in some cases, the causative pathogen may continue circulating within the herd or flock.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Effective tylosin use should therefore be part of a broader process that includes:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diagnosis.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Selection of the correct product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monitoring treatment response.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental management.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antimicrobial resistance control.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Compliance with withdrawal periods.<\/span><\/li>\n<\/ul>\n<h2><b>When a Herd or Flock Has Respiratory Disease, Look Beyond Tylosin<\/b><\/h2>\n<p><b>Is the disease actually caused by Mycoplasma or another susceptible bacterium?<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">Respiratory signs alone are not sufficient to identify the causative pathogen.<\/span><\/p>\n<p><b>Does treatment only reduce clinical signs, or does it control the source of infection?<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">Clinical improvement may occur in some cases while <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> continues circulating within the herd or flock.<\/span><\/p>\n<p><b>Are housing conditions contributing to recurrence?<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">Ventilation, stocking density, hygiene, breeding stock, and biosecurity all influence respiratory disease risk.<\/span><\/p>\n<p><b>Which tylosin formulation is being used?<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">Tylosin tartrate, tylosin phosphate, and injectable formulations have different instructions for use.<\/span><\/p>\n<p><b>Has the withdrawal period been managed after treatment?<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">The withdrawal period must be determined according to the exact product, animal species, route of administration, and type of food product.<\/span><\/p>\n<h2><b>1. Why Is Tylosin Commonly Associated with Respiratory Disease in Animals?<\/b><\/h2>\n<figure id=\"attachment_20853\" aria-describedby=\"caption-attachment-20853\" style=\"width: 1033px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20853\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1330728771-612x612-1.jpg\" alt=\"Laboratory technician examining a sample under a microscope to identify pathogens associated with respiratory disease\" width=\"1043\" height=\"695\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1330728771-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1330728771-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 1043px) 100vw, 1043px\" \/><figcaption id=\"caption-attachment-20853\" class=\"wp-caption-text\">Tylosin is a macrolide antibiotic with activity against certain susceptible bacteria and Mycoplasma; treatment effectiveness depends on the pathogen, susceptibility, infection site, and animal health status.<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Tylosin is an antibiotic belonging to the <\/span><b>macrolide<\/b><span style=\"font-weight: 400;\"> class.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It binds to the <\/span><b>50S subunit of the bacterial ribosome<\/b><span style=\"font-weight: 400;\">, thereby disrupting protein synthesis required for cell growth and multiplication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tylosin is primarily <\/span><b>bacteriostatic<\/b><span style=\"font-weight: 400;\">, meaning that it inhibits the growth of susceptible bacteria.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, this mechanism does not mean that tylosin is suitable for every bacterial infection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Actual effectiveness also depends on:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bacterial species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bacterial strain.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Susceptibility to tylosin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Site of infection.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severity of disease.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ability of the drug to reach the infection site.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Health status of the animal.<\/span><\/li>\n<\/ul>\n<h3><b>Spectrum of activity of tylosin<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tylosin has activity against:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Many susceptible Gram-positive bacteria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some Gram-negative bacteria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some susceptible <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Its activity against Gram-negative bacteria is generally more limited than against Gram-positive bacteria.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tylosin does not directly act against:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viruses.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fungi.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parasites.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Therefore, when respiratory or gastrointestinal disease is caused by these groups of pathogens, tylosin cannot be considered a direct treatment.<\/span><\/p>\n<h2><b>2. When Does Mycoplasma Make Tylosin Relevant?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">One reason tylosin is commonly discussed in veterinary medicine is its activity against some susceptible <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> strains.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In pigs and poultry, <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> may be associated with important respiratory diseases.<\/span><\/p>\n<h3><b>In poultry<\/b><\/h3>\n<p><i><span style=\"font-weight: 400;\">Mycoplasma gallisepticum<\/span><\/i><span style=\"font-weight: 400;\"> is one of the important pathogens associated with respiratory disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In some infections involving susceptible <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">, clinical signs may improve when tylosin is used according to an appropriate indication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, improvement in clinical signs does not mean that the pathogen has been completely eliminated from the flock.<\/span><\/p>\n<h3><b>In pigs<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some tylosin products may be used in the management of respiratory diseases associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">, depending on:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The pathogen.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product indications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Target animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disease situation on the farm.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Tylosin should not be used automatically simply because pigs:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have difficulty breathing.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eat less.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Grow poorly.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These signs may occur in many different diseases.<\/span><\/p>\n<h2><b>3. Reduced Clinical Signs Do Not Mean Mycoplasma Has Been Eliminated from the Herd or Flock<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">This is an important point when evaluating the effectiveness of tylosin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The sequence can be illustrated as follows:<\/span><\/p>\n<p><b>Respiratory signs decrease<\/b><b><br \/>\n<\/b><span style=\"font-weight: 400;\">\u2193<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Animals appear to recover<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u2193<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">But the pathogen may not have been completely eliminated<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u2193<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Some animals may continue carrying or circulating the pathogen<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u2193<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">Disease may reappear when conditions become favorable<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Control of respiratory disease associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> should therefore not rely solely on a single course of antibiotics.<\/span><\/p>\n<h3><b>Review the breeding stock<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If the pathogen is repeatedly introduced through:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breeding animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Replacement stock.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Newly introduced animals.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">then treating individual disease episodes may not address the underlying source.<\/span><\/p>\n<h3><b>Manage newly introduced animals<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Appropriate procedures should address:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Origin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Health monitoring.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quarantine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Observation before introduction into the herd or flock.<\/span><\/li>\n<\/ul>\n<h3><b>Biosecurity<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Attention should be paid to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People entering and leaving.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vehicles.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Equipment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Movement between different areas.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cleaning and disinfection.<\/span><\/li>\n<\/ul>\n<h3><b>Housing environment<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Respiratory disease may become more severe when:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ventilation is poor.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritating gas concentrations are high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Humidity is inappropriate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stocking density is high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Litter or flooring is poorly managed.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Therefore:<\/span><\/p>\n<p><b>Antibiotic treatment may be one part of disease control, but it cannot replace herd or flock management and environmental management.<\/b><\/p>\n<h2><b>4. Pigs, Poultry, and Cattle Do Not Share the Same Indication Logic<\/b><\/h2>\n<figure id=\"attachment_20855\" aria-describedby=\"caption-attachment-20855\" style=\"width: 902px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20855\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1273010540-612x612-1.jpg\" alt=\"Pig and chicken in a livestock setting illustrating tylosin use across different animal species\" width=\"912\" height=\"608\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1273010540-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1273010540-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 912px) 100vw, 912px\" \/><figcaption id=\"caption-attachment-20855\" class=\"wp-caption-text\">Tylosin may be used in certain diseases in pigs and poultry, but product formulation, indication, route of administration, and withdrawal requirements must be checked separately for each species.<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Some tylosin products are used in:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pigs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poultry.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cattle.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However, this does not mean that one product can be used in the same way across all three groups.<\/span><\/p>\n<h3><b>Pigs<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some products may be indicated for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Respiratory diseases associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> or susceptible bacteria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain gastrointestinal diseases according to the product indication.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Selection should be based on:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pathogen.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product formulation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Route of administration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disease situation within the herd.<\/span><\/li>\n<\/ul>\n<h3><b>Poultry<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tylosin is often considered for certain respiratory diseases associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, it is necessary to check:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Poultry species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Age group.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product formulation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Production purpose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Whether the flock is raised for meat or egg production.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In particular, a product approved for broiler chickens is not automatically permitted for <\/span><b>laying hens producing eggs for human consumption<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><b>Cattle<\/b><\/h3>\n<figure id=\"attachment_20857\" aria-describedby=\"caption-attachment-20857\" style=\"width: 830px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20857\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1578413182-612x612-1.jpg\" alt=\"Cattle in a pasture illustrating veterinary tylosin use in beef and dairy animals\" width=\"840\" height=\"560\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1578413182-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1578413182-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 840px) 100vw, 840px\" \/><figcaption id=\"caption-attachment-20857\" class=\"wp-caption-text\">Some tylosin products may be registered for cattle, but beef and dairy cattle must be distinguished, especially when milk is being produced for human consumption.<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Some products may be registered for use in cattle.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, it is still necessary to determine:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Whether the animal is beef or dairy cattle.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Whether milk is currently being produced for human consumption.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product indications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Applicable withdrawal period.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If the label does not permit use in cattle producing milk for human consumption, a withdrawal period should not be guessed and applied on your own.<\/span><\/p>\n<h2><b>5. Tylosin May Also Be Used for Certain Gastrointestinal Diseases<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Although tylosin is often discussed in relation to respiratory disease, some products may also be indicated for gastrointestinal diseases caused by susceptible bacteria.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, diarrhea is not a diagnosis.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Possible causes include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bacteria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viruses.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parasites.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feed changes.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nutritional imbalance.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drinking water.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Housing conditions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stress.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Therefore:<\/span><\/p>\n<p><b>Not every case of diarrhea requires an antibiotic.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">If the disease:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Persists.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recurs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Affects multiple animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Causes increasing mortality.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Does not respond to initial measures.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">the underlying cause should be reassessed before continuing or changing antibiotic treatment.<\/span><\/p>\n<h2><b>6. How Do Tylosin Tartrate, Tylosin Phosphate, and Injectable Formulations Differ?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The name \u201ctylosin\u201d on a label is not enough to determine how the product should be used.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common formulations may include:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Product form<\/b><\/td>\n<td><b>May be found in<\/b><\/td>\n<td><b>What should be checked<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Tylosin tartrate<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Some products administered through drinking water or another approved route<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Concentration, route of administration, species, and indication<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Tylosin phosphate<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Some feed-administered products or other formulations<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intended use, applicable regulations, and withdrawal period<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Injectable formulations<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Some products designed for injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Correct species, approved injection route, warnings, and withdrawal period<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><b>Tylosin tartrate<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tylosin tartrate is found in some products designed for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Administration through drinking water.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use by another approved route.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Specific instructions must be checked on the product label.<\/span><\/p>\n<h3><b>Tylosin phosphate<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tylosin phosphate may be present in products administered:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Through feed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Or in other forms depending on the product.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For products administered through feed, particular attention should be paid to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intended purpose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Current regulations.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Approved target animals.<\/span><\/li>\n<\/ul>\n<h3><b>Injectable formulations<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some tylosin products are formulated for injection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Do not apply:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The dose of a drinking-water product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Instructions for a feed-administered product.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">to an injectable product.<\/span><\/p>\n<h3><b>Do not interchange products based only on the active ingredient name<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Do not independently:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inject a product intended for drinking water.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use an injectable product in drinking water.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Apply tylosin tartrate instructions to tylosin phosphate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Apply the withdrawal period of one product to another.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Although they all contain tylosin, products may differ in:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Formulation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Route of administration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Target animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal period.<\/span><\/li>\n<\/ul>\n<h2><b>7. If Disease Does Not Improve After Tylosin Treatment: Check These 5 Possibilities<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">A poor response to treatment should not immediately be addressed by increasing the dose or switching to another antibiotic.<\/span><\/p>\n<h3><b>1. Was the original diagnosis correct?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The disease may be caused by:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viruses.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pathogens not susceptible to tylosin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multiple pathogens acting together.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental conditions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If the underlying cause is not appropriate for tylosin, the drug may not produce the expected result.<\/span><\/p>\n<h3><b>2. Is the pathogen actually susceptible to tylosin?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The name of a bacterium or <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> alone is not enough to conclude that every strain is susceptible.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Susceptibility may vary according to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Strain.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Farm.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Geographic area.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of antibiotic use.<\/span><\/li>\n<\/ul>\n<h3><b>3. Are the product and route of administration appropriate?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Check:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Which tylosin formulation is being used.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Target species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Route of administration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Expiry date.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Storage conditions.<\/span><\/li>\n<\/ul>\n<h3><b>4. Are farm conditions contributing to continued recurrence?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ventilation is poor.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stocking density is too high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Newly introduced animals repeatedly bring in pathogens.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity is inadequate.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">then disease may recur even when treatment provides temporary improvement.<\/span><\/p>\n<h3><b>5. Is tylosin resistance possible?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Antimicrobial resistance should be considered when:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clinical signs do not improve.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disease recurs quickly.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multiple animals fail to respond.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The effectiveness of the same treatment protocol declines over time.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Morbidity or mortality increases.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">However:<\/span><\/p>\n<p><b>Treatment failure alone is not sufficient to conclude that the bacteria are resistant to tylosin.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">When necessary, a veterinarian may recommend:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sample collection.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bacterial culture.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Identification of the causative organism.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antimicrobial susceptibility testing.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do not independently increase the dose, extend treatment, or add another antibiotic without reassessing the cause.<\/span><\/p>\n<h2><b>8. How Does Tylosin Resistance Develop?<\/b><\/h2>\n<figure id=\"attachment_20859\" aria-describedby=\"caption-attachment-20859\" style=\"width: 880px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20859\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2241417347-612x612-1.jpg\" alt=\"Researcher analyzing laboratory data related to tylosin antimicrobial resistance\" width=\"890\" height=\"593\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2241417347-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2241417347-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 890px) 100vw, 890px\" \/><figcaption id=\"caption-attachment-20859\" class=\"wp-caption-text\">Tylosin resistance occurs when bacteria develop mechanisms that reduce the drug\u2019s effectiveness, including target-site changes, drug efflux, enzymatic inactivation, or acquisition of resistance genes.<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">Tylosin resistance occurs when <\/span><b>bacteria<\/b><span style=\"font-weight: 400;\"> are able to withstand the effects of the drug.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is not a situation in which the animal\u2019s body \u201cgets used to the medicine.\u201d<\/span><\/p>\n<h3><b>Some mechanisms of resistance<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Bacteria may:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alter the drug\u2019s target site on the ribosome.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase drug efflux from the cell.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Produce enzymes that inactivate the drug.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acquire resistance genes from other bacteria.<\/span><\/li>\n<\/ul>\n<h3><b>Selection pressure<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">A bacterial population may already contain some organisms with resistance characteristics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When an antibiotic is used:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Susceptible bacteria are inhibited.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Resistant bacteria gain a survival advantage.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The resistant population may gradually increase.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Inappropriate antibiotic use increases this selection pressure.<\/span><\/p>\n<h3><b>Practices to avoid<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Using tylosin without an appropriate indication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Using a dose or method that differs from approved instructions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Repeating the same old protocol for every disease episode.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Extending treatment without reassessment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Combining multiple antibiotics without professional guidance.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Routinely using antibiotics instead of disease-prevention measures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Failing to maintain medication-use records.<\/span><\/li>\n<\/ul>\n<h3><b>Cross-resistance<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Some resistance mechanisms may reduce bacterial susceptibility not only to tylosin but also to other related antibiotics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This makes antimicrobial resistance management more important than simply \u201cswitching to another antibiotic\u201d when the current treatment protocol becomes less effective.<\/span><\/p>\n<h2><b>9. Tylosin in Feed and Disease Prevention from 2026 Onward<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Three purposes need to be distinguished:<\/span><\/p>\n<p><b>Disease treatment<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Using an antibiotic when animals have developed an appropriate bacterial infection requiring treatment.<\/span><\/p>\n<p><b>Disease control<\/b><\/p>\n<p><span style=\"font-weight: 400;\">May be applied in certain situations when disease has already appeared and a group of animals is at risk, subject to appropriate professional and legal conditions.<\/span><\/p>\n<p><b>Disease prevention<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Using an antibiotic before disease appears in order to prevent infection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These three purposes are not the same.<\/span><\/p>\n<h3><b>Do not routinely use tylosin as a substitute for disease prevention<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Farms should not rely on tylosin or other antibiotics instead of:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hygiene.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaccination.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herd or flock management.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental control.<\/span><\/li>\n<\/ul>\n<h3><b>Regulatory considerations from 2026<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">According to Article 12 of Decree No. 13\/2020\/ND-CP and the amendments and supplements consolidated in <\/span><b>Consolidated Document No. 23\/VBHN-BNNMT of 2026<\/b><span style=\"font-weight: 400;\">, the final deadline for the use of approved antibiotic groups for disease prevention in animal feed was <\/span><b>December 31, 2025<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Therefore, from 2026 onward, livestock facilities need to pay particular attention to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Purpose of use.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Method of use.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Regulations currently in force.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Regulations on antibiotics in animal feed for disease-prevention purposes should be distinguished from veterinary medicines used for treatment or disease control where such use is lawful and appropriately indicated.<\/span><\/p>\n<h2><b>10. Control Respiratory Disease at Herd or Flock Level to Reduce Reliance on Tylosin<\/b><\/h2>\n<figure id=\"attachment_20861\" aria-describedby=\"caption-attachment-20861\" style=\"width: 910px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20861\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1257912433-612x612-1.jpg\" alt=\"Veterinarian examining calves as part of herd health monitoring and respiratory disease prevention\" width=\"920\" height=\"579\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1257912433-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-1257912433-612x612-1-300x189.jpg 300w\" sizes=\"(max-width: 920px) 100vw, 920px\" \/><figcaption id=\"caption-attachment-20861\" class=\"wp-caption-text\">Reducing reliance on tylosin requires herd-level measures such as breeding-stock management, ventilation, stocking-density control, hygiene, biosecurity, and disease monitoring.<\/figcaption><\/figure>\n<p><span style=\"font-weight: 400;\">If respiratory disease repeatedly returns, farms should ask:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhy does the herd or flock keep getting sick?\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">rather than only:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhich antibiotic should we use next time?\u201d<\/span><\/p>\n<h3><b>Manage breeding stock<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The source of breeding animals may influence whether pathogens continue circulating.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Management should address:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Source of introduced animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Health history.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Receiving procedures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Quarantine.<\/span><\/li>\n<\/ul>\n<h3><b>Improve ventilation<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Appropriate ventilation helps control:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Humidity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heat.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritating gases.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dust.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Air quality.<\/span><\/li>\n<\/ul>\n<h3><b>Control stocking density<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Excessive stocking density may:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase contact between animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce air quality.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increase stress.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Facilitate rapid disease transmission.<\/span><\/li>\n<\/ul>\n<h3><b>Hygiene and biosecurity<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Management should cover:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Equipment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vehicles.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Movement flows.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Areas housing sick animals.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Waste.<\/span><\/li>\n<\/ul>\n<h3><b>Monitor disease data<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Farms should record:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When disease appears.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Location.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Age group.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Morbidity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mortality.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Products used.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment response.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recurrence.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These data help determine whether the disease is:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An isolated outbreak.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Or an ongoing systemic problem.<\/span><\/li>\n<\/ul>\n<h2><b>11. Tylosin Withdrawal Periods and Residue Control<\/b><\/h2>\n<p><b>There is no single withdrawal period that applies to all tylosin products.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">The withdrawal period depends on:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Salt form.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Formulation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Route of administration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dose and treatment regimen.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Animal species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Type of food product.<\/span><\/li>\n<\/ul>\n<h3><b>Broilers and laying hens are not the same<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">A product approved for broiler chickens is not automatically permitted for laying hens producing eggs for human consumption.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If a product is not approved for laying hens:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use it automatically.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not invent an egg withdrawal period to \u201ccompensate\u201d for the restriction.<\/span><\/li>\n<\/ul>\n<h3><b>Cattle and lactating dairy cattle must also be distinguished<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Even when a product is labeled for cattle, check separately:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Is it permitted for dairy cattle?<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are there restrictions during milk production?<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">What is the withdrawal period for milk?<\/span><\/li>\n<\/ul>\n<h3><b>Procedure for checking the withdrawal period<\/b><\/h3>\n<p><b>Step 1: Identify the exact product<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Check:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trade name.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ingredients.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Concentration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dosage form.<\/span><\/li>\n<\/ul>\n<p><b>Step 2: Confirm the correct species and production category<\/b><\/p>\n<p><span style=\"font-weight: 400;\">For example:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pigs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Broiler chickens.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Laying hens.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Beef cattle.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dairy cattle.<\/span><\/li>\n<\/ul>\n<p><b>Step 3: Check the withdrawal period<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Read the information separately for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Meat.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Milk.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eggs.<\/span><\/li>\n<\/ul>\n<p><b>Step 4: Record the time of the last dose<\/b><\/p>\n<p><span style=\"font-weight: 400;\">This is the reference point for determining the withdrawal period.<\/span><\/p>\n<p><b>Step 5: Confirm when sale is permitted<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Animals or animal products should enter the food chain only after:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The withdrawal period has ended.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Conditions of use have been met.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relevant legal requirements have been satisfied.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If the label does not provide appropriate information, do not assume that <\/span><b>no withdrawal period is required<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><b>MRL and withdrawal period are not the same<\/b><\/h3>\n<p><b>MRL \u2013 Maximum Residue Limit<\/b><span style=\"font-weight: 400;\"> is the maximum permitted level of a veterinary drug residue in the relevant food product under the applicable regulation or standard.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In contrast, the <\/span><b>withdrawal period<\/b><span style=\"font-weight: 400;\"> is the period that must be observed after the last dose of a specific product under defined conditions of use.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MRLs may vary according to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Active ingredient.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Type of food.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Market.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For exported products, additional requirements of the importing country should also be checked.<\/span><\/p>\n<ol start=\"12\">\n<li><b> Recording Tylosin Use on the Farm<\/b><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">Medication records help:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Monitor treatment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Control withdrawal periods.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Identify repeated use.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Support traceability when needed.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Important information includes:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Information<\/b><\/td>\n<td><b>Purpose<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Product name, active ingredient, batch number<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Identify the exact product<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Individual animal ID or treated group<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Identify which animals received the medicine<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Start and end dates<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Monitor the treatment course<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Use information according to instructions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Verify how the medicine was administered<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Time of the last dose<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Establish the withdrawal reference point<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Withdrawal end date<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Manage sale or harvesting of animal products<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prescriber and person administering treatment<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Support management and traceability<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Large farms may use:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herd or flock management software.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Electronic records.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal-alert systems.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Regardless of the system used, data should be:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Accurate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Up to date.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Searchable.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Consistent across departments.<\/span><\/li>\n<\/ul>\n<h2><b>Frequently Asked Questions About Veterinary Tylosin<\/b><\/h2>\n<figure id=\"attachment_20863\" aria-describedby=\"caption-attachment-20863\" style=\"width: 892px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-20863\" src=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2227822382-612x612-1.jpg\" alt=\"Stethoscope and FAQ letters illustrating frequently asked questions about tylosin in veterinary medicine\" width=\"902\" height=\"601\" srcset=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2227822382-612x612-1.jpg 612w, https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/istockphoto-2227822382-612x612-1-300x200.jpg 300w\" sizes=\"(max-width: 902px) 100vw, 902px\" \/><figcaption id=\"caption-attachment-20863\" class=\"wp-caption-text\">Tylosin cannot treat every respiratory disease in animals; its use should be based on diagnosis, the causative organism, antimicrobial susceptibility, and the indication of the exact product.<\/figcaption><\/figure>\n<h3><b>Can tylosin treat every respiratory disease in animals?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">No.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Respiratory disease may be caused by:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viruses.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bacteria.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multiple pathogens acting together.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental conditions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Tylosin is appropriate only when the causative organism and product indication are suitable.<\/span><\/p>\n<h3><b>Is tylosin effective against Mycoplasma?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Tylosin has activity against some susceptible <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> strains and is used in certain products for diseases associated with these pathogens.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, effectiveness depends on:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Strain.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Susceptibility.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Animal species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disease condition.<\/span><\/li>\n<\/ul>\n<h3><b>Does tylosin treatment completely eliminate Mycoplasma from a herd or flock?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">This should not be assumed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some cases may show:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced clinical signs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Improved clinical condition.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">while the pathogen may continue circulating.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Control therefore also requires:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breeding-stock management.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Environmental management.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Health surveillance.<\/span><\/li>\n<\/ul>\n<h3><b>Why does respiratory disease recur after treatment?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Possible reasons include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The pathogen continues circulating.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Newly introduced animals bring in infection.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ventilation remains inadequate.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stocking density is high.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity is insufficient.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The pathogen is not susceptible.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antimicrobial resistance.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Co-infection.<\/span><\/li>\n<\/ul>\n<h3><b>Should tylosin be used routinely for disease prevention?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">No.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antibiotics should not be routinely used as a substitute for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaccination.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hygiene.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Biosecurity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herd or flock management.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">From 2026 onward, livestock facilities also need to pay particular attention to current regulations concerning the use of antibiotics in animal feed for disease-prevention purposes.<\/span><\/p>\n<h3><b>Can tylosin be used in laying hens?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">It depends on the specific product.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some products may have an appropriate scope of use, while others may have:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restrictions.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Contraindications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Specific requirements.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do not apply the instructions for one product to another.<\/span><\/p>\n<h3><b>Why might animals fail to recover despite tylosin treatment?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Possible reasons include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Incorrect diagnosis.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A non-susceptible pathogen.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antimicrobial resistance.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wrong product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inappropriate use.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Co-infection.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ongoing disease pressure from farm conditions.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do not independently increase the dose or change antibiotics without reassessment.<\/span><\/p>\n<h3><b>What is the withdrawal period for tylosin?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">There is no single withdrawal period for all products.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It must be determined according to the:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Exact product.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Species.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dosage form.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Route of administration.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Meat, milk, or eggs involved.<\/span><\/li>\n<\/ul>\n<h2><b>From Respiratory Disease Control to Evidence-Based Tylosin Use at VIETSTOCK 2026<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Tylosin is commonly considered for respiratory diseases associated with <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\"> in pigs and poultry, but coughing or difficulty breathing does not automatically mean that tylosin is the appropriate choice. Even when the medicine improves clinical signs, the pathogen may remain within the herd or flock. Long-term effectiveness therefore also depends on diagnosis, biosecurity, breeding-stock management, and accompanying disease-prevention measures.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At <\/span><b>VIETSTOCK 2026<\/b><span style=\"font-weight: 400;\">, livestock producers and businesses can examine respiratory disease from a broader perspective than a single medication protocol. The event is expected to bring together <\/span><b>300 brands<\/b><span style=\"font-weight: 400;\">, cover <\/span><b>10,000 sqm of exhibition area<\/b><span style=\"font-weight: 400;\">, and welcome around <\/span><b>13,000 trade visitors from 40 countries<\/b><span style=\"font-weight: 400;\">, giving participants access to a wide range of veterinary, disease-prevention, and herd or flock management solutions. Areas worth prioritizing include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Respiratory disease diagnostic solutions:<\/b><span style=\"font-weight: 400;\"> support differentiation between cases involving bacteria, <\/span><i><span style=\"font-weight: 400;\">Mycoplasma<\/span><\/i><span style=\"font-weight: 400;\">, or other pathogens before selecting an antibiotic.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Veterinary medicines and tylosin products:<\/b><span style=\"font-weight: 400;\"> compare dosage forms, routes of administration, target animals, and product limitations rather than applying the same approach based only on the active ingredient name.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Biosecurity and breeding-stock management:<\/b><span style=\"font-weight: 400;\"> explore measures that help limit pathogen circulation and recurrence after treatment.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Housing environment and farm conditions:<\/b><span style=\"font-weight: 400;\"> review ventilation, stocking-density, and environmental-management solutions that may help reduce respiratory disease pressure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Medication records and traceability:<\/b><span style=\"font-weight: 400;\"> explore tools that support monitoring of treatment courses, the last dose, withdrawal periods, and the herd or flock\u2019s treatment history.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For farms facing recurrent disease or repeated antibiotic use, the <\/span><b>One Health Forum<\/b><span style=\"font-weight: 400;\"> on <\/span><b>October 22, 2026<\/b><span style=\"font-weight: 400;\"> offers a broader approach than simply switching to another active ingredient.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The forum features a session on <\/span><b>\u201cDigitalization of Hygiene and Biosecurity Practices on Livestock Farms\u201d<\/b><span style=\"font-weight: 400;\">, providing insights into the application of digital technologies in farm hygiene management and disease risk prevention. This session is particularly relevant for farms seeking to improve livestock housing conditions, minimize infection risks, and establish proactive disease prevention practices rather than focusing solely on treating individual respiratory disease outbreaks.<\/span><\/p>\n<p><b>Date:<\/b><span style=\"font-weight: 400;\"> October 21\u201323, 2026<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>Venue:<\/b><span style=\"font-weight: 400;\"> Saigon Exhibition and Convention Center \u2013 SECC, 799 Nguyen Van Linh Street, Tan My Ward, Ho Chi Minh City, Vietnam<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>Event website:<\/b><a href=\"https:\/\/www.vietstock.org\/en\/\"> <span style=\"font-weight: 400;\">VIETSTOCK 2026<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\ud83d\udc49<\/span><a href=\"https:\/\/ers-vn.informa-info.com\/vs26\"> <b>Register to Visit VIETSTOCK 2026<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\ud83d\udc49<\/span><a href=\"https:\/\/www.vietstock.org\/en\/uncategorized\/vietstock-2026-pre-registration-is-now-open-connect-with-the-future-of-livestock-production-and-animal-health\/\"> <b>Visitor Registration Information<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\ud83d\udc49<\/span><a href=\"https:\/\/www.vietstock.org\/en\/event-news-en\/one-health-forum-at-vietstock-2026-advancing-sustainable-livestock-development\/\"> <b>Learn More About the One Health Forum<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\ud83d\udc49<\/span><a href=\"https:\/\/www.vietstock.org\/en\/event-features\/vietstock-2026-shaping-the-future-of-the-livestock-industry-through-innovation-green-transition-and-competitiveness-enhancement\/\"> <b>Explore Innovation, Green Transition and Competitiveness at VIETSTOCK 2026<\/b><\/a><\/p>\n<p><b>Contact information:<\/b><\/p>\n<p><b>Exhibiting:<\/b><span style=\"font-weight: 400;\"> Ms. Sophie Nguyen \u2013 Sophie.nguyen@informa.com<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>Group Delegation Support:<\/b><span style=\"font-weight: 400;\"> Ms. Phuong \u2013 Phuong.c@informa.com<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>Marcom Support:<\/b><span style=\"font-weight: 400;\"> Ms. Anita Pham \u2013 Anita.pham@informa.com<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tylosin is a macrolide antibiotic used in veterinary medicine for certain susceptible bacterial infections, including some Mycoplasma-associated respiratory diseases. Learn about its uses, product formulations, antimicrobial resistance, herd-level disease control, and withdrawal-period considerations.<\/p>\n","protected":false},"author":3,"featured_media":20868,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v15.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tylosin in Veterinary Medicine: Uses, Resistance &amp; Withdrawal<\/title>\n<meta name=\"description\" content=\"Learn how tylosin is used in veterinary medicine, including Mycoplasma-related disease, product forms, resistance risks, and withdrawal periods.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tylosin in Veterinary Medicine: Uses, Resistance &amp; Withdrawal\" \/>\n<meta property=\"og:description\" content=\"Learn how tylosin is used in veterinary medicine, including Mycoplasma-related disease, product forms, resistance risks, and withdrawal periods.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\" \/>\n<meta property=\"og:site_name\" content=\"Vietstock Expo and Forum\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-13T02:31:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-13T06:35:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/veterinary-tylosin-uses-resistance-withdrawal.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\">\n\t<meta name=\"twitter:data1\" content=\"17 minutes\">\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.vietstock.org\/#website\",\"url\":\"https:\/\/www.vietstock.org\/\",\"name\":\"Vietstock Expo and Forum\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/www.vietstock.org\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/#primaryimage\",\"inLanguage\":\"en\",\"url\":\"https:\/\/www.vietstock.org\/wp-content\/uploads\/2026\/10\/veterinary-tylosin-uses-resistance-withdrawal.jpg\",\"width\":1200,\"height\":675,\"caption\":\"Tylosin is used in veterinary medicine for certain infections caused by susceptible organisms, particularly some Mycoplasma-associated respiratory diseases in pigs and poultry.\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/#webpage\",\"url\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\",\"name\":\"Tylosin in Veterinary Medicine: Uses, Resistance & Withdrawal\",\"isPartOf\":{\"@id\":\"https:\/\/www.vietstock.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/#primaryimage\"},\"datePublished\":\"2026-10-13T02:31:30+00:00\",\"dateModified\":\"2026-10-13T06:35:19+00:00\",\"author\":{\"@id\":\"https:\/\/www.vietstock.org\/#\/schema\/person\/caaf897414eac1b9f130df4ddb9e34d6\"},\"description\":\"Learn how tylosin is used in veterinary medicine, including Mycoplasma-related disease, product forms, resistance risks, and withdrawal periods.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/#breadcrumb\"},\"inLanguage\":\"en\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.vietstock.org\/en\/\",\"url\":\"https:\/\/www.vietstock.org\/en\/\",\"name\":\"Trang ch\\u1ee7\"}},{\"@type\":\"ListItem\",\"position\":2,\"item\":{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\",\"url\":\"https:\/\/www.vietstock.org\/en\/industry-news\/tylosin-veterinary-medicine-uses-resistance-withdrawal\/\",\"name\":\"Tylosin in Veterinary Medicine: Scope of Use, Antimicrobial Resistance, and Residue Considerations\"}}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.vietstock.org\/#\/schema\/person\/caaf897414eac1b9f130df4ddb9e34d6\",\"name\":\"vietwatercc\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.vietstock.org\/#personlogo\",\"inLanguage\":\"en\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/1f8963694a555b77c6f4e61284c4fadb?s=96&d=mm&r=g\",\"caption\":\"vietwatercc\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/posts\/20867"}],"collection":[{"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/comments?post=20867"}],"version-history":[{"count":1,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/posts\/20867\/revisions"}],"predecessor-version":[{"id":20870,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/posts\/20867\/revisions\/20870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/media\/20868"}],"wp:attachment":[{"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/media?parent=20867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/categories?post=20867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vietstock.org\/en\/wp-json\/wp\/v2\/tags?post=20867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}